| Citation | Dr. FitzGerald's research has been characterized by an integrative approach to elucidating the mechanisms of drug action. He was the first to describe the dose dependent suppression by aspirin of thromboxane and prostacyclin biosynthesis in vivo. His work contributed substantially to the development of low-dose aspirin. FitzGerald's group was the first to predict and then mechanistically explain the cardiovascular hazard from NSAIDs. Aside from this work, FitzGerald has also discovered many products of lipid peroxidation and established their utility as indices of oxidant stress in vivo. His laboratory was the first to discover a molecular clock in the cardiovascular system and has contributed substantially to our understanding of the importance of peripheral clocks in the regulation of cardiovascular and metabolic function |