Record

RefNoEC/2013/19
LevelItem
TitleHawkins, Philip Thomas: certificate of election to the Royal Society
Date2 May 2013
DescriptionCertificate of Election
CitationPhill Hawkins has made many outstanding contributions to knowledge of the variety and functions of inositol lipids and polyphosphates in eukaryotic cells, most of them jointly with his long-time collaborator Len Stephens. Discovery of Ins(3,4,5,6)P4 and pyrophosphorylated derivatives of InsP6 and proof that cells contain 3-phosphorylated derivatives of phosphatidylinositol (PtdIns) were early highlights. They then showed that PtdIns(4,5)P2 is the main substrate of receptorcontrolled phosphoinositide 3-kinases (PI3Ks), identifying PtdIns(3,4,5)P3 as a key signal in stimulated cells. They and Alessi (FRS 2008) discovered, in parallel, that phosphoinositidedependent kinase-1 (PDK1) is the PtdIns(3,4,5)P3-activated link between PI3K and protein kinase B, defining a key pathway through which PtdIns(3,4,5)P3 regulates cell proliferation and survival.
Having identified and characterised the GPCR-activated Type 1B PI3K (PI3K) and explained its complex regulation by G and Ras-GTP, they used mutant mice to demonstrate the contributions of PI3K and other PI3K isoforms to inflammatory events in vivo. They have also: defined the pathway from PI3K activation, via Rac activation, to cytoskeletal reorganization; identified multiple PtdIns(3,4,5)P3 effectors; demonstrated that interaction between PtdIns3P and a protein PX domain is essential for activation of the bacteriocidal oxidase of neutrophils; and developed a sensitive MS-based assay for polyphosphoinositides in cell extracts. Following Len Stephens's election in 2011, it would be appropriate to elect his long-term and equal scientific partner.
Extent2p
FormatPrinted
AccessStatusClosed
Add to My Items

    Collection highlights

    Browse the records of some of our collections, which cover all branches of science and date from the 12th century onwards. These include the published works of Fellows of the Royal Society, personal papers of eminent scientists, letters and manuscripts sent to the Society or presented at meetings, and administrative records documenting the Society's activities since our foundation in 1660.

    The Royal Society

    The Royal Society is a Fellowship of many of
    the world's most eminent scientists and is the
    oldest scientific academy in continuous existence.
    Registered charity number 207043

    Website design ©CalmView



    CONTACT US

    + 44 207 451 2500
    (Lines open Mon-Fri, 9:00-17:00. Excludes bank holidays)

    6-9 Carlton House Terrace, London SW1Y 5AG

    Email Us →

    SUBSCRIBE

    Subscribe to our newsletters to be updated with the
    latest news on innovation, events, articles and reports.

    Subscribe →

    © CalmView