| Citation | Chris Schofield is an international-leader in functional, structural and mechanistic studies on enzymes in particular those employing oxygen and 2-oxoglutarate cosubstrates. His work has opened up new fields in antibiotic research, oxygen sensing and gene regulation. After groundbreaking work on plant and microbial oxygenases, he pioneered structurally informed functional assignments for uncharacterised oxygenases. His research identified unanticipated roles for oxygenases in regulating gene expression, importantly in the hypoxic response, and revealed new modifications to chromatin, RNA splicing proteins and ribosomes. The work has identified new opportunities for medicinal intervention that are being pursued by numerous academic and commercial laboratories. |