| Citation | Professor in Cell Biology, MRC Clinical Sciences Centre, Imperial College London
Amanda Fisher is distinguished for her pioneering work on HIV pathogenesis, T lymphocyte development, embryonic stem cells and epigenetic gene regulation. She described the first active clones of HIV and discovered the functions of several HIV genes including tat, nef and vif. In T lymphocytes she showed that a gene's position within the nucleus is important for maintaining heritable gene silencing. In embryonic stem cells she showed that important developmental regulator genes can be "poised" for expression whilst being repressed by polycomb repressor complexes.
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