| Citation | Professor Jane Clarke, Wellcome Trust Senior Research Fellow and Professor of Molecular Biophysics, Department of Chemistry, University of Cambridge
Jane Clarke is distinguished for the rigorous physical chemistry approaches she has adapted and applied to understand protein folding and misfolding. Her fundamental studies revealed the presence of both parallel pathways and frustration in the energy landscape of apparently simple proteins. Most significantly, she has made very important advances in the study of larger multidomain systems. From her discovery that aggregation and misfolding are determined by sequence similarity, through to her seminal studies combining force spectroscopy and protein engineering to elucidate mechanical unfolding energy landscapes, Jane has transformed our understanding of the evolution, folding and energetics of multidomain proteins.
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