| Citation | Antony Galione is distinguished for his pioneering work that has transformed our understanding of calcium signalling pathways. His innovative research has established the concept of multiple calcium mobilizing messengers, and identified their target channels and organelles. He established that cyclic ADP-ribose regulates calcium-induced calcium release and globalization of calcium signals, and that NAADP is a ubiquitous trigger for initiating and coordinating calcium signals. By developing novel pharmacological, molecular and physiological approaches, he has demonstrated that these novel messengers selectively control many fundamental cellular processes. His discovery of lysosomes as calcium stores mobilized by NAADP, has identified an entirely new signalling role for these organelles in health and disease |