Citation | Richard Harvey is a pioneer of the molecular era of cardiac development. His discovery of the homeodomain transcription factor Nkx2-5 provided the entry point for molecular dissection of heart development and congenital heart disease mechanisms in humans. His discovery of new patterning principals that govern heart development and the multiple roles played by Nkx2-5 in heart formation, dysregulated in disease, have redefined our understanding of the developing heart and opened the doors to systems level analysis. |