RefNo | EC/2022/54 |
Level | Item |
Title | De Lange, Titia: certificate of election to the Royal Society |
Date | 21 April 2022 |
Description | Certificate endorsing election of Titia de Lange as a Foreign Member of the Royal Society. Includes personal details of the elected Foreign Member, citation giving the reasons for election, and names of proposers. Signed by the Executive Director of the Royal Society, Julie Maxton. |
Citation | Professor de Lange’s work answered a long-standing question in cell biology: how do the ends of linear chromosomes avoid being detected and processed as sites of DNA damage? De Lange identified the first mammalian telomericspecific binding protein and showed that telomeres are protected by a six-subunit shelterin complex. She uncovered how shelterin uses ssDNA binding proteins and the now classic T-loop structure to avoid recognition by the DNA damage signalling proteins ATM and ATR and repair factors. Professor de Lange’s pioneering work on the telomere protection has profound implications for our understanding of cell proliferation, genome instability, and cancer. |
Extent | 4p |
Format | Computer printout |
PhysicalDescription | A4 papers |
AccessStatus | Closed |
AccessConditions | Election certificates are subject to 50 year closure period from date of election. Details of proposers and date certificate was first submitted for candidacy are kept confidential until the 50 year closure period has elapsed. |