Record

Authorised form of nameNagai; Kiyoshi (1949 - 2019)
Dates1949 - 2019
NationalityJapanese
Place of birthOsaka, Japan, Asia
Date of birth25/06/1949
Place of deathCambridge, Cambridgeshire, England, United Kingdom
Date of death27/09/2019
OccupationBiologist
Research fieldBiophysics
Crystallography
Proteins
RNA
ActivityEducation:
Osaka University, Japan, BS in Biophysics (1972); Osaka University Postgraduate School, Japan, MS in Biophysics (1974), PhD in Biophysics (1977)
Career:
Member of Scientific Staff, MRC Laboratory of Molecular Biology, Cambridge (1974-1976); Postdoctoral Fellow, Japanese Society for Peomotion of Science (1977-1978); Assistant Professor, Department of Physiology, NAra MEdical COllege (1978-1981); Postdoctoral Fellow, Medical Research Council Laboratory of Molecular Biology, Cambridge (1981-1984); Member of Scientific Staff, MRC Laboratory of molecular Biology, Cambridge (1984-2019)
Memberships:
Fellow of Darwin College, University of Cambridge (1993); European Molecular Biology Organization (2000)
Medals and Awards:
Novartis Medal and Prize of the Biochemical Society, 2000
Membership categoryFellow
Date of election11/05/2000
Age at election50
PublishedWorkshttps://orcid.org/0000-0003-1785-6510
OtherInfoKiyoshi Nagai was a structural biologist who studied the complex molecular machine known as the spliceosome. In eukaryotic cells, the protein-coding sequences of most genes are interrupted by noncoding segments called introns. After introns are removed from precursor messenger RNAs (mRNAs), the flanking coding segments — exons — are spliced together to form mature mRNAs by the spliceosome.

If this splicing process fails, diseases can result. Kiyoshi combined X-ray crystallography and electron cryomicroscopy (cryoEM) with biochemical and genetic techniques in an effort to increase our knowledge of this critical process in eukaryotic gene expression.

Professor Kiyoshi Nagai FRS died on 27 September 2019.
SourceSources:
https://royalsociety.org/people/kiyoshi-nagai-11991/
https://en.wikipedia.org/wiki/Kiyoshi_Nagai
Virtual International Authority Filehttp://viaf.org/viaf/32147687
CodeNA3081
Archives associated with this Fellow
RefNoTitleDate
EC/2000/26Nagai, Kiyoshi: certificate of election to the Royal Society
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