Record

Authorised form of name	Yanofsky; Charles (1925 - 2018)
Dates	1925 - 2018
Nationality	American
Place of birth	New York, New York, USA
Date of birth	17/04/1925
Date of death	16/03/2018
Occupation	Geneticist
Research field	Genetics
Membership category	Foreign Member
Date of election	27/06/1985
Age at election	60
OtherInfo	Charles Yanofsky was a geneticist and molecular biologist. His research focused on the control of gene expression, and he specifically investigated how protein manufacture at the cellular level — a process known as transcription — is controlled in bacteria. He established the ‘one gene–one protein’ principle, which describes the linear relationship between a gene and the specific protein that it encodes. Through his research, Charles showed that the sequence of nitrogen bases in DNA relates exactly to the sequence of amino acids in the protein that the gene codes for. He found that changing the sequence of bases resulted in a corresponding change in the amino acid sequence. Charles went on to investigate the control of production of the amino acid tryptophan in Escherichia coli bacteria. He found that the bacterial cells could sense how much tryptophan was already present and reduce or stop transcription as necessary. For this important research, Charles won a number of awards, including the prestigious US National Medal of Science in 2003. Professor Charles Yanofsky ForMemRS died on 16 March 2018.
Source	References: R Holliday, 'The early years of molecular biology: personal recollections' in NR 2003 vol 57 pp 195-208
Virtual International Authority File	http://viaf.org/viaf/14252049
Code	NA4754

Archives associated with this Fellow

RefNo	Title	Date
EC/1985/46	Yanofsky, Charles: certificate of election to the Royal Society	1985

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