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Authorised form of nameSambrook; Joseph Frank (1939 - 2019)
Dates1939 - 2019
NationalityBritish
Place of birthLiverpool, Merseyside, England, United Kingdom
Date of birth01/03/1939
Date of death14/06/2019
OccupationMolecular biologist
Research fieldBiochemical genetics
Molecular virology
Cancer cells
ActivityEducation:
University of Liverpool BSc hons (1962); Australian National University, PhD (1966)
Career:
Postdoctoral researcher, Medical Research Council Laboratory of Molecular Biology (1966 -1967), postdoctoral researcher Salk Institute for Biological Studies (1967-1969) ; Cold Spring Harbor Laboratory (1969); University of Texas Southwestern Medical Centre Dallas; Peter MacCallum Cancer Centre (1995); Executive Scientific Director of the Stem Cell Centre Monash University; founding Director of kConFaB, Australia's National Consortium for Research into Familial Breast Cancer
Memberships:
FAA
Membership categoryFellow
Date of election21/03/1985
Age at election46
RelationshipsHired to work at Cold Spring Harbor Laboratory by James Watson FRS
OtherInfoJoseph Sambrook made many important contributions to molecular and biochemical genetics, studying animal viruses, and particularly those viruses with DNA that integrate into the host cell genome. He was a member of the group that first demonstrated the physical integration of the DNA sequences of SV40 and other polyoma viruses into the chromosomes of the cells they transform. He subsequently defined the sequences which are necessary and sufficient to effect malignant transformation, and was a pioneer in the use of restriction enzymes for the physical mapping of mutations in adenovirus. He was the first to analyse the DNA sequences of the integration sites of SV40, work that confirmed the ‘onion skin’ model of excision. Joseph also analysed the expression of influenza virus haemagglutinin from genes cloned in SV40 vectors and studied the factors influencing the transport of haemagglutinin to the cell surface by in vitro modification of the genes.
SourceSources:
https://web.archive.org/web/20120317114007/http://www.thankyouday.org/ThankYouDayAwards/ThankYouDayAwards2009.aspx
Reference:
https://en.wikipedia.org/wiki/Joseph_Sambrook
Virtual International Authority Filehttp://viaf.org/viaf/41900839
CodeNA4781
Archives associated with this Fellow
RefNoTitleDate
EC/1985/34Sambrook, Joseph Frank: certificate of election to the Royal Society1984
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