| Authorised form of name | Jackson; Richard James (1940 - 2020) |
| Dates | 1940 - 2020 |
| Nationality | British |
| Place of birth | Bournemouth, Bournemouth, England, United Kingdom |
| Date of birth | 01/07/1940 |
| Date of death | 21/09/2020 |
| Occupation | Biochemist |
| Research field | Biology |
| Cell biology |
| Proteins |
| Ribosomes |
| Messenger RNA |
| Activity | Education:
University of Cambridge, PhD
Career:
Professor of RNA (later Emeritus), Department of Biochemistry, University of Cambridge
Memberships:
European Molecular Biology Organisation
|
| Membership category | Fellow |
| Date of election | 18/05/2006 |
| Age at election | 65 |
| PublishedWorks | Jackson RJ (2013). The current status of vertebrate cellular mRNA IRESs. Cold Spring Harb. Perspect. Biol., 5(2):a011569. doi: 10.1101/cshperspect.a011569
Pöyry TA, Kaminski A, Connell EJ, Fraser CS, Jackson RJ (2007). The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation. Genes Dev., 21(23):3149-3162. doi: 10.1101/gad.439507
Kafasla P, Morgner N, Pöyry TA, Curry S, Robinson CV, Jackson RJ (2009). Polypyrimidine tract binding protein stabilizes the encephalomyocarditis virus IRES structure via binding multiple sites in a unique orientation. Mol. Cell, 34(5):556-568. doi: 10.1016/j.molcel.2009.04.015
Kafasla P, Morgner N, Robinson CV, Jackson RJ (2010). Polypyrimidine tract-binding protein stimulates the poliovirus IRES by modulating eIF4G binding. EMBO J., 29(21):3710-3722. doi: 10.1038/emboj.2010.231
Pöyry TA, Jackson RJ (2011). Mechanisms governing the selection of translation initiation sites on foot-and-mouth disease virus RNA. J. Virol., 85(19):10178-10188. doi: 10.1128/JVI.05085-11 |
| OtherInfo | Richard Jackson made major contributions to cell biology, focusing on the moment at which ribosomes within the cell begin to translate the cell’s genetic instructions, in the form of messenger RNA (mRNA), into protein products. Understanding how the cell regulates this translation process has significant implications for new therapies in cancer and a range of viral diseases.
Eleven different eukaryotic initiation factors, or eIFs, participate in regulating translation, and Richard developed standard methods of studying their interactions in cultured cells. He explored how these factors enable the ribosome to select the correct initiating site by scanning from one end of an mRNA molecule.
He also investigated ‘internal ribosome entry segments’ (IRESs) in both cellular and viral mRNA where ribosomes initiate translation directly. Richard continued to study the way IRESs enable viruses to subvert the host’s protein production machinery.
Professor Richard Jackson FRS died on 21 September 2020. |
| Source | Sources:
https://royalsociety.org/people/richard-jackson-11688/ (accessed 29 September 2020) |
| Code | NA9218 |
Archives associated with this Fellow
| RefNo | Title | Date |
| EC/2006/20 | Jackson, Richard James: certificate of election to the Royal Society | |
| IM/006294 | Jackson, Richard James | July 2006 |